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Microfluidics and nanofluidics are among the most rapidly growing fields of scientific research and technology development. Over the past 15 years, the research activities in these fields have been increasing exponentially as evidenced by the number of published papers in the literature. Microfluidics and nanofluidics not only bring exciting opportunities to study the new phenomena unique to these small scales, but also enable the development of many new and high-impact technologies from handheld biomedical laboratory (Lab-on-a-Chip) to detection and manipulation of single molecules. While these exciting and inter-disciplinary research fields attract more and more researchers, one major challenge is the lack of a single reference resource providing up-to-date reviews and overviews of various directions in the field of microfluidics and nanofluidics. This is the motivation behind the development of the Encyclopedia of Microfluidics and Nanofluidics. As a comprehensive resource, no single review paper or several books focused on specific topics can replace the role of an Encyclopedia.